HIV-1 protease inhibitors based on acyclic carbohydrates

DOI: 10.1021/jo971562c

Source and publish data:

Journal of Organic Chemistry p. 4898 - 4906 (1998)

Update date:2022-08-05

Topics: Experimental terms Chemical terms HIV-1 Protease inhibitors

Authors:

Zuccarello, Guido

Bouzide, Abderrahim

Kvarnstroem, Ingemar

Niklasson, Gunilla

Svensson, Stefan C. T.

Brisander, Magnus

Danielsson, Helena

Nillroth, Ulrika

Karlen, Anders

Hallberg, Anders

Classon, Bjoern

Samuelsson, Bertil

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Article abstract of DOI:10.1021/jo971562c

A series of acyclic C₂-symmetric HIV protease inhibitors readily accessible from D-mannitol have been developed. Several of the compounds synthesized showed significant in vitro activity against HIV-1 protease.

Full text of DOI:10.1021/jo971562c

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