Enzymatic desymmetrization of prochiral 2-benzyl-1,3-propanediol derivatives: A practical chemoenzymatic synthesis of novel phosphorylated tyrosine analogues

DOI: 10.1016/S0040-4020(98)00586-9

Source and publish data:

Tetrahedron p. 9341 - 9356 (1998)

Update date:2022-08-04

Topics:

Authors:

Yokomatsu, Tsutomu

Minowa, Takayuki

Murano, Tetsuo

Shibuya, Shiroshi

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Article abstract of DOI:10.1016/S0040-4020(98)00586-9

(Phosphonomethyl)phenylalanine (Pmp) and (phosphonodifluoromethyl)phenylalanine (F₂Pmp) as well as their β-amino acid congeners were prepared as a protecting variant amenable to the peptide synthesis from readily available 2-benzyl-1,3-propandiols possessing either a diethylphosphonomethyl- or diethylphosphonodifluoromethyl functionality at the para-position via the lipase-catalyzed desymmetrization.

Full text of DOI:10.1016/S0040-4020(98)00586-9

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Product name:dimethyl 2-[3-(diethoxyphosphorylmethyl)benzyl]malonate

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