PdI2-catalyzed regioselective cyclocarbonylation of 2-allyl phenols to dihydrocoumarins

DOI: 10.1021/ol5029157

Source and publish data:

Organic Letters p. 5827 - 5829 (2014)

Update date:2022-07-31

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Authors:

Amzquita-Valencia, Manuel

Alper, Howard

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Article abstract of DOI:10.1021/ol5029157

A simple, efficient, and regioselective synthesis of 3-methyl-3,4-dihydrocoumarins is reported. The reaction of 2-allyl phenols with synthesis gas was catalyzed by PdI₂, and 1,3,5,7-tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane (L1) and 1,3,5,7-tetramethyl-6-tetradecyl-2,4,8-trioxa-6-phosphaadamantane (L2) were effective as ligands, affording good product selectivity in all cases.

Full text of DOI:10.1021/ol5029157

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