Synthesis and characterization of α-phosphorylated ketones: Models for the molybdopterin precursor

Article abstract of DOI:10.1016/S0040-4020(98)00663-2

Synthesis of pyridyl substituted α-keto six membered cyclic phosphates is reported. These compounds are structurally similar to the precursor of molybdopterin (MPT), an important biological cofactor. We demonstrate that these α-phosphorylated ketones can undergo the fundamental transformation required for MFF synthesis.