Studies on pyrrolidinones. Synthesis of N-benzhydrylpyroglutamic acids and esters

DOI: 10.1002/jhet.5570350312

Source and publish data:

Journal of Heterocyclic Chemistry p. 567 - 573 (1998)

Update date:2022-08-04

Topics:

Authors:

Rigo, Benoit

Gautret, Philippe

Legrand, Anne

Henichart, Jean Pierre

Couturier, Daniel

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Article abstract of DOI:10.1002/jhet.5570350312

Catalyzed N-alkylation of N,O-bistrimethylsilyl pyroglutamic acid with trimethylsilyl benzhydryl ethers yields trimethylsilyl N- benzhydrylpyroglutamates. Hydrolysis of these compounds or saponification of the methyl esters gives the corresponding acids.

Full text of DOI:10.1002/jhet.5570350312

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