Studies on pyrrolidinones. Synthesis of N-benzhydrylpyroglutamic acids and esters

Article abstract of DOI:10.1002/jhet.5570350312

Catalyzed N-alkylation of N,O-bistrimethylsilyl pyroglutamic acid with trimethylsilyl benzhydryl ethers yields trimethylsilyl N- benzhydrylpyroglutamates. Hydrolysis of these compounds or saponification of the methyl esters gives the corresponding acids.