Positioning of functionalities in a heteroduplex major groove: Synthesis of 7-deaza-2-amino-2'-deoxyadenosines

Article abstract of DOI:10.1080/07328319708006111

We have synthesized the 7-iodo-, 7-cyano- and 7-propynyl-7-deaza-2- amino-2'-deoxyadenosines and incorporated each into several oligonucleotide (ODN) sequences. These oligonucleotides exhibit enhanced binding affinities to RNA complements relative to unmo

Full text of DOI:10.1080/07328319708006111

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Nucleosides and Nucleotides
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Positioning of Functionalities in
a Heteroduplex Major Groove:
Synthesis of 7-Deaza-2-Amino-2′-
deoxyadenosines
Guity Balow a , John Brugger a , Elena Lesnik a & Oscar L.
Acevedo a
a Isis Pharmaceuticals , Carlsbad, CA, 92008
Published online: 16 Aug 2006.
To cite this article: Guity Balow , John Brugger , Elena Lesnik & Oscar L. Acevedo
(1997) Positioning of Functionalities in a Heteroduplex Major Groove: Synthesis of 7-
Deaza-2-Amino-2′-deoxyadenosines, Nucleosides and Nucleotides, 16:7-9, 941-944, DOI:
10.1080/07328319708006111
To link to this article: http://dx.doi.org/10.1080/07328319708006111
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