Bioorganic and Medicinal Chemistry Letters p. 2253 - 2258 (1998)
Update date:2022-08-03
Topics:
Goulet, Mark T.
McAlpine, Shelli R.
Staruch, Mary Jo
Koprak, Samuel
Dumont, Francis J.
Cryan, John G.
Wiederrecht, Gregory J.
Rosa, Raymond
Wilusz, Mary Beth
Peterson, Laurence B.
Wyvratt, Matthew J.
Parsons, William H.
A series of C32-O-aralkyl ether derivatives of the FK-506 related macrolide ascomycin have been prepared based on an earlier reported C32-O- cinnamyl ether design. In the present study, the nature of the aryl tethering group was varied in an attempt to improve oral activity. An imidazol-2-yl- methyl tether was found to be superior among those investigated and has resulted in an ascomycin analog, L-733,725, with in vivo immunosuppressive activity comparable to FK-506 but with an improved therapeutic index.
View MoreShijiazhuang City Xiehe Pharmaceutical Co., Ltd
Contact:+86-311-80817929
Address:Shangzhuang,Shijiazhuang,China
ZiBO KuoDing Trade company Ltd
website:http://www.sdzbkd.com
Contact:86-13361591822
Address:GongQingTuan road
Taizhou volsen chemical Co., Ltd
website:http://www.volsenchem.com
Contact:+86-576-88869393
Address:Jiaojiang District, Taizhou, Zhejiang, China.
Jiangsu Allyrise Pharmaceutical Co., Ltd.(expird)
Contact:+86-523-86818997
Address:Taizhou,Jiangsu Province,CHINA
Zhejiang Hoshine Silicon Industry Co., Ltd.
Contact:86-573-89179966
Address:Zhapu Town, Pinghu City, Zhejiang, China
Doi:10.1021/jo020256i
(2002)Doi:10.1039/c4ra16760k
(2015)Doi:10.1021/jm9604078
(1996)Doi:10.1016/S1381-1169(99)00244-7
(2000)Doi:10.1016/S0040-4039(98)01553-6
(1998)Doi:10.1080/07328319908044614
(1999)
