Synthetic studies on halichondrin B, an antitumor polyether macrolide isolated from a marine sponge. 9. Synthesis of the C16 - C36 unit via stereoselective construction of the D and E rings

DOI: 10.1248/cpb.46.1199

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1199 - 1216 (1998)

Update date:2022-07-30

Topics:

Authors:

Horita, Kiyoshi

Nagasawa, Masaaki

Sakurai, Youji

Yonemitsu, Osamu

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.46.1199

The C16 - C36 unit of halichondrin B was stereoselectively synthesized via the aldol condensation of two C16 - C26 esters with the previously synthesized C27 - C36 aldehyde followed by E ring construction. The C16 - C26 esters were prepared starting from (2S)-3-hydroxy-2-methylpropionic acid and L-tartaric acid via construction of the D ring by iodoetherification.

Full text of DOI:10.1248/cpb.46.1199

NII-Electronic Library Service

Products guided by the article

Product name:methyl (2E,5R)-6-(tert-butyldiphenylsilyloxy)-5-methyl-2-hexenoate

Cas No:214532-98-6

R&D Labs maybe for 214532-98-6

Jiaxing Carry Bio-Chem Technology Co.,Ltd

website:http://www.carrybiotech.com

Contact:0573-82788958

Address:Add.Fl 3th, Pharm Vally,Kaichuang Rd, Xiuzhou District, Jiaxing, Zhejiang,314031,China
LINYI FUDE FINE CHEMICAL CO.,LTD

Contact:86-539-2361184

Address:YISHUI, LINYI,SAHNDONG,CHINA
Beijing ZhongDaXinHe Chemical Product Co.,Ltd(expird)

Contact:010-52876516

Address:tongzhoubeiyuan
Zhuhai Rundu Pharmaceutical co.,Ltd

Contact:+86-756-7630755

Address:No.6,North Airport Road,Sanzao Town,Jinwan District
Changzhou Welton Chemical Co., Ltd,

Contact:0086-519-85910828,85920537,85912897

Address:No.8 Jinlong Road, Binjiang Park, Changzhou, Jiangsu, China.

Relevant to this article

Design and synthesis of analogs of vitamin E: Antiproliferative activity against human breast adenocarcinoma cells

Doi:10.1016/S0960-894X(98)00438-7
(1998)
Structural, spectroscopic and electrochemical investigations on fluorinated meso -tetraaryl porphyrins

Doi:10.1142/S108842461750064X
(2017)
Doi:10.1007/BF01154328
(1968)
The synthesis of cyclic alpha-amino acids. II.

Doi:10.1246/bcsj.42.194
(1969)
Preparation of L-lyxo-hexos-5-ulose through C-3 epimerization of bis-glycopyranosides of L-arabino-hexos-5-ulose 1

Doi:10.1080/07328309808001891
(1998)
Transition-metal-substituted phosphanes, arsanes and stibanes, LXIII.: Coupling reactions of alkynes with iron coordinated diphenylphosphane: Generation of an alkenylphosphane and a chelating bisphosphane ligand 1

Doi:10.1016/S0022-328X(98)00806-7
(1998)

Article Doi