Synthetic studies on halichondrin B, an antitumor polyether macrolide isolated from a marine sponge. 9. Synthesis of the C16 - C36 unit via stereoselective construction of the D and E rings

DOI: 10.1248/cpb.46.1199

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1199 - 1216 (1998)

Update date:2022-07-30

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Authors:

Horita, Kiyoshi

Nagasawa, Masaaki

Sakurai, Youji

Yonemitsu, Osamu

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Article abstract of DOI:10.1248/cpb.46.1199

The C16 - C36 unit of halichondrin B was stereoselectively synthesized via the aldol condensation of two C16 - C26 esters with the previously synthesized C27 - C36 aldehyde followed by E ring construction. The C16 - C26 esters were prepared starting from (2S)-3-hydroxy-2-methylpropionic acid and L-tartaric acid via construction of the D ring by iodoetherification.

Full text of DOI:10.1248/cpb.46.1199

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