
Tetrahedron Letters p. 7211 - 7214 (1998)
Update date:2022-09-26
Topics:
East, Stephen P.
Joullie, Madeleine M.
A strained 14-membered cyclopeptide was prepared from the Garner aldehyde derived from D-serine. The key steps in the synthesis were the construction of the alkyl-aryl ether linkage via an S(N)Ar reaction involving 4-fluorobenzonitrile and the macrolactamization using a modification of the Schmidt protocol involving an activated pentafluorophenyl ester.
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