Preparation and evaluation of a cyclic acyl nitrone as a synthon for stereospecific α-amino acid synthesis

DOI: 10.1016/S0040-4039(98)01474-9

Source and publish data:

Tetrahedron Letters p. 6819 - 6822 (1998)

Update date:2022-08-02

Topics:

Authors:

Baldwin, Steven W.

Young, Bruce G.

McPhail, Andrew T.

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Article abstract of DOI:10.1016/S0040-4039(98)01474-9

The preparation and characterization of cyclic optically active (5R)- 3,4,5,6-tetrahydro-5-phenyl-2H-1,4-oxazin-2-one-N-oxide (2) is described. This nitrone, which is viewed as a template for the synthesis of γ- oxygenated α-amino acids, reacts with alkenes efficiently and with high stereospecificity.

Full text of DOI:10.1016/S0040-4039(98)01474-9

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