Synthesis of Key Intermediates

Asymmetric synthesis Characterization Optimization Protecting groups Deprotection Biological testing Protection of Functional Groups Glycosylation Retrosynthetic analysis Purification and characterization Scale-up and optimization Final steps Structure-Activity Relationship (SAR) Studies Workup and Purification Scale-up Stereochemistry Control Purification and Isolation Stereochemical Control Literature Review Biological Evaluation Structure-Activity Relationship (SAR) Study Safety and Toxicity Assessment In Vivo Studies Lead Optimization Global Deprotection Asymmetric Hydrogenation Ring Formation Stereochemical Considerations Functional Group Transformations Safety and Environmental Considerations Analog Synthesis Safety and Ethical Considerations Introduction of fluorine atoms Optimization and Yield Improvement Key Intermediates Completion and Optimization Functional Group Protection Nucleoside Formation