Metal complexes of alkyne-bridged α-amino acids

Article abstract of DOI:10.1002/(SICI)1099-0682(199811)1998:11<1791::AID-EJIC1791>3.0.CO;2-H

The palladium-mediated coupling of p-ethynylphenylalanine (p-epa) with different halogenated benzenes yielded alkyne-bridged α-amino acids. A series of cationic mono- to hexanuclear (Ph₃P)₂Pt complexes with the anions of p-ethynylphenylalanine and alkynyl- or benzene-bridged di-, tri-, tetra- and hexa-ethynyl phenylalanines as N,O-chelate ligands was prepared. N-t-Boc-p-ethynylphenylalanine methyl ester was metal-substituted to give complexes of the types Ph₃PAu-C≡C-R and (Et₃P)₂Pt-(C≡CR)₂. The benzene-bridged di-, tri-, tetra- and hexa-p-ethynylphenylalanine methyl esters form Schiff bases with ferrocene aldehyde and a tripodal ligand was obtained from. Ph₂PCH₂CH₂CH₂NH₂ and the benzene-bridged triethynylphenyl-alanine. The structure of (Ph₃P)₂Pt[NH₂C(H)-(CH₂C ₆H₄C≡CH)CO₂]⁺ BF₄^- was determined by X-ray diffraction.