Tetrahedron Letters p. 8373 - 8376 (1998)
Update date:2022-08-04
Topics:
Zhou, Jinglan
Shevlin, Philip B.
A convenient synthesis of racemic 2'-deoxy carbocyclic thymidines lacking the 5'-methylene group is reported. Thus, appropriately protected nucleic acid bases are coupled to 3-cyclopentenol, 1, via the Mitsunobu reaction. Epoxidation of the protected thymine substituted cyclopentene gives the corresponding syn and anti-epoxides in a 4:1 ratio. Ring opening of the syn-epoxide by a variety of nucleophiles leads to the racemic 2'-deoxy carbocyclic thymidines lacking the 5'-methylene group.
View MoreTianjin Jiuri New Materials Co., Ltd.
Contact:+86-22-58889220
Address:C-5/6, Vison Hill, No.1 Gonghua Road, Huayuan Hi-tech Park, Tianjin, China.
Taizhou Huading Chemical Co.,Ltd(expird)
Contact:+86-576-88583898
Address:Economic&Technology development zone,Taizhou City,Zhejiang Province,China
Contact:+86-27-67841589
Address:Add: 999 Gaoxin Road, Donghu New Technology Development Zone, Wuhan City, Hubei, China
Contact:+86-10-83993285
Address:Rm.1708, Haobai Tower, Building 6, No.50, North Road, West Third Ring, Haidian District, Beijing, China
Shanghai Send Pharmaceutical Technology Co., Ltd.
website:http://www.shsendpharma.com
Contact:021-58088081, +8613585868794
Address::Room A601, Building 1,NO. 800 Qingdai Road Pudong District Shanghai,China
Doi:10.1021/ja301334b
(2012)Doi:10.1139/v65-024
(1965)Doi:10.1016/S0040-4039(98)01901-7
(1998)Doi:10.1016/S0040-4039(98)02000-0
(1998)Doi:10.1055/s-0036-1591566
(2018)Doi:10.1021/om980823l
(1998)