Design and synthesis of dipeptidyl α',β'-epoxy ketones, potent irreversible inhibitors of the cysteine protease cruzain

DOI: 10.1016/S0960-894X(98)00494-6

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2809 - 2812 (1998)

Update date:2022-08-04

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Authors:

Roush, William R.

Gonzalez, Florenci V.

McKerrow, James H.

Hansell, Elizabeth

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Article abstract of DOI:10.1016/S0960-894X(98)00494-6

The dipeptidyl epoxy ketone 4 is a potent, irreversible inhibitor of cruzain, a cysteine protease isolated from Trypanosoma cruzi, with an apparent second order inhibition rate constant of 330,000 sec^-1 M^-1.

Full text of DOI:10.1016/S0960-894X(98)00494-6

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