Design and synthesis of dipeptidyl α',β'-epoxy ketones, potent irreversible inhibitors of the cysteine protease cruzain

Article abstract of DOI:10.1016/S0960-894X(98)00494-6

The dipeptidyl epoxy ketone 4 is a potent, irreversible inhibitor of cruzain, a cysteine protease isolated from Trypanosoma cruzi, with an apparent second order inhibition rate constant of 330,000 sec^-1 M^-1.