Design and synthesis of dipeptidyl α',β'-epoxy ketones, potent irreversible inhibitors of the cysteine protease cruzain

DOI: 10.1016/S0960-894X(98)00494-6

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2809 - 2812 (1998)

Update date:2022-08-04

Topics:

Authors:

Roush, William R.

Gonzalez, Florenci V.

McKerrow, James H.

Hansell, Elizabeth

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(98)00494-6

The dipeptidyl epoxy ketone 4 is a potent, irreversible inhibitor of cruzain, a cysteine protease isolated from Trypanosoma cruzi, with an apparent second order inhibition rate constant of 330,000 sec^-1 M^-1.

Full text of DOI:10.1016/S0960-894X(98)00494-6

Products guided by the article

Product name:[(1S,2S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-but-3-enyl]-carbamic acid benzyl ester

Cas No:218774-04-0

R&D Labs maybe for 218774-04-0

SHANGHAI BIOSUNDRUG CO.,LTD.

Contact:86-21-34622192，13917187091，21-34622765

Address:No. 500 Caobao Road Shanghai P.R China
Jiangxi Dongbang Pharmaceutical Co., Ltd.

Contact:+86-795-4433603, 4433388

Address:Fengxin Industrial Park, Fengxin County, Jiangxi Province, P.R.C
Chengdu Pukang Biotechnology Co., Ltd

website:http://www.pu-kang.com

Contact:86-028-63976226

Address:No. 868 Xiwang Road,Xinjin county,Chengdu city, China
Xinchang Jiu Xin Pharmaceutical Co., Ltd

website:http://www.jiuxinpharm.com

Contact:86 137 5756 8585

Address:Poyang industry Park
Beijing Green Guardee Technology CO,.LTD

Contact:+86-10-69706062

Address:F2 BLdj,5 No.37 Chaoqian Road

Relevant to this article

Synthesis of 1-β-L-arabinofuranosylcytosine (β-L-Ara-C) and 2'-deoxy- 2'-methylene-β-L-cytidine (β-L-DMDC) as potential antineoplastic agents

Doi:10.1080/15257779408010669
(1994)
A novel method for the formation of 2-azocanones by lactone-to-lactam ring contraction of 2-oxonanones

Doi:10.1016/S0040-4039(98)02093-0
(1998)
pH Dependence of the Elimination of Isoquinolines from N-(2-Cyanoethyl)isoquinolinium Cations

Doi:10.1021/ja00188a047
(1989)
Bronsted acidic ionic liquid based magnetic nanoparticles: A new promoter for the Biginelli synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones

Doi:10.1039/c3nj01065a
(2014)
High yield preparation of a novel tetrakis[ruthenium tris(bipyridine)]calix[6]arene derivative with good diastereomeric purity

Doi:10.1016/S0957-4166(98)00433-9
(1998)
Doi:10.1021/ja01482a026
(1961)

Article Doi