Chemistry of Heterocyclic Compounds p. 459 - 462 (1998)
Update date:2022-08-03
Topics:
Abele
Abele
Ruhina
Gaukhman
Lukevics
We have investigated the alkylation of 2-methyl-5-ethynylpyridine by butyl bromide in liquid/liquid and liquid/solid two-phase catalytic systems. We have shown that the catalytic system solid KOH/18-crown-6/CuBr/toluene is the most active in this reaction; using this system, we obtained alkylation products of ethynylpyridines in 34-43% yields. 1998 Plenum Publishing Corporation.
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