Synthesis of C-ring aromatic taxoids and evaluation of their multi-drug resistance reversing activity

DOI: 10.1016/S0960-894X(98)00539-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2973 - 2976 (1998)

Update date:2022-09-26

Topics:

Authors:

Morihira, Koichiro

Nishimori, Toshiyuki

Kusama, Hiroyuki

Horiguchi, Yoshiaki

Kuwajima, Isao

Tsuruo, Takashi

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(98)00539-3

The C-aromatic taxoids were synthesized to develop effective inhibitors against drug efflux mediated by p-glycoproteins. Among those tested using multi-drug resistant tumor cells (2780AD), the benzoate 11 exhibited significant activity as potent as verapa

Full text of DOI:10.1016/S0960-894X(98)00539-3

Products guided by the article

Product name:(S)-1-[(S)-(2-[1,3]Dioxolan-2-yl-6-methoxymethoxy-phenyl)-hydroxy-methyl]-4,6,6-trimethyl-5-[1-phenylsulfanyl-meth-(E)-ylidene]-3-triisopropylsilanyloxy-cyclohex-3-enol

Cas No:219523-58-7

R&D Labs maybe for 219523-58-7

WUHAN RISON TRADING CO.,LTD

Contact:0086-27-83607103/83642615

Address:No.498, Jianshe Ave, Wuhan, China
Shanghai KFSL Pharmaceutical Technology Co.,Ltd.

Contact:+86-21-39971718

Address:859 jiadingchengliu shanghai
Jingzhou TianHe Sci&Tech Chemical Co., Ltd.

Contact:86-716-8331612

Address:Jiangjin Road, #18, High-grade technology industries development district, Jingzhou city, Hubei province
SHANDONG AONA CHEMICAL CO.,LTD.

Contact:86-532-85762926

Address:LIUYUAN TOWN, ZAOZHUANG CITY, SHANGDONG PROVINCE.
Jurong Huaheng Natural Biological Products Factory

website:http://www.risebiochem.com

Contact:+86-13921007726

Address:Chuncheng town,Jurong city,Jiangsu province,China

Relevant to this article

Synthesis of 9-membered masked enediyne analogues possessing DNA intercalator and sugar moieties

Doi:10.1016/S0960-894X(98)00605-2
(1998)
Total synthesis of myxalamide A

Doi:10.1021/jo9813742
(1999)
Generation and trapping of N-acyliminium ions derived from isomunchnone cycloadducts. A versatile route to functionalized heterocycles

Doi:10.1021/jo981624e
(1999)
Synthesis and characterization of 14-electron cyclopentadienyl chromium(II) complexes containing a heterocyclic carbene ligand

Doi:10.1021/om980799b
(1999)
A stereoselective synthesis via a 5-exo-trig cyclisation of trans-2-oxohexahydro-2H-furo[3,2-b]pyrroles (pyrrolidine-trans-lactones) - Potent, novel elastase inhibitors

Doi:10.1039/a807540i
(1998)
Stereocontrol during the formation of 2-C mono-arylated pseudo-prolines by aromatic stacking interaction

Doi:10.1016/S0040-4020(98)01039-4
(1999)

Article Doi