Synthesis of C-ring aromatic taxoids and evaluation of their multi-drug resistance reversing activity

DOI: 10.1016/S0960-894X(98)00539-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2973 - 2976 (1998)

Update date:2022-09-26

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Authors:

Morihira, Koichiro

Nishimori, Toshiyuki

Kusama, Hiroyuki

Horiguchi, Yoshiaki

Kuwajima, Isao

Tsuruo, Takashi

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Article abstract of DOI:10.1016/S0960-894X(98)00539-3

The C-aromatic taxoids were synthesized to develop effective inhibitors against drug efflux mediated by p-glycoproteins. Among those tested using multi-drug resistant tumor cells (2780AD), the benzoate 11 exhibited significant activity as potent as verapa

Full text of DOI:10.1016/S0960-894X(98)00539-3

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