Tetrahedron Letters p. 8991 - 8994 (1998)
Update date:2022-07-30
Topics:
Asseline, Ulysse
Roig, Victoria
Thuong, Nguyen T.
Solid-phase synthesis of 5'-5'-linked oligonucleotides with opposite polarities tethered via nucleic bases has been performed using a modified dinucleoside bearing an H-phosphonate group at the 3'-position of one nucleoside and a dimethoxytrityl group at the 3'-position of the second nucleoside. This system is aimed at forming a base tetrad at the junction in order to provide better stabilization. The linker used between the two 5'- terminal bases in the same plane involves a triple bond in order to rigidify the junction. The two oligonucleotide chains are either made of natural nucleosides or one of them is built with N3'→P5' phosphoramidates.
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