Novel benzopyrano[3,4-c]pyrrole derivatives as potent and selective dopamine D3 receptor antagonists

DOI: 10.1016/S0960-894X(99)00312-1

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2059 - 2064 (1999)

Update date:2022-07-30

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Authors:

Dubuffet, Thierry

Newman-Tancredi, Adrian

Cussac, Didier

Audinot, Valerie

Loutz, Annie

Millan, Mark J.

Lavielle, Gilbert

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Article abstract of DOI:10.1016/S0960-894X(99)00312-1

A new series of benzopyrano[3,4-c]pyrrole derivatives were synthesized and evaluated for their interaction with dopamine D₃ versus D₂ receptors. Amongst these compounds, 4x (S 33084) was found to be a potent and selective dopamine D₃ receptor antagonist.

Full text of DOI:10.1016/S0960-894X(99)00312-1

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