Synthetic studies toward potent cytotoxic agents amphidinolides: Synthesis of the C1-C18 moiety of amphidinolides G, H and L

Article abstract of DOI:10.1016/S0040-4039(98)02009-7

Stereoselective synthesis of the (8S, 9S, 11R, 16S)-C₁-C₁₈ segment 1 of amphidinolides G, H and L, bearing the unique trisubstituted 's-cis-1,3- diene' moiety (C(28(29))=C₁₃-C₁₄=C₁₅), has been achieved for the first time following a highly efficient convergent strategy.