Unexpected reactivity of N2-benzylidene guanosine derivatives

DOI: 10.1016/S0040-4039(98)02074-7

Source and publish data:

Tetrahedron Letters p. 9183 - 9186 (1998)

Update date:2022-08-03

Topics:

Authors:

Mons, Stephane

Lebeau, Luc

Mioskowski, Charles

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Article abstract of DOI:10.1016/S0040-4039(98)02074-7

Guanosine derivatives masked at the sugar are protected at N² by a benzylideneamine group for the first time. The free 5'-hydroxyl function reveals to be incompatible with the N²-protective group that is then rapidly hydrolyzed to regenerate the free exocyclic amine.

Full text of DOI:10.1016/S0040-4039(98)02074-7

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