Restricting the flexibility of crosslinked, interfacial peptide inhibitors of HIV-1 protease

Article abstract of DOI:10.1016/S0960-894X(98)00595-2

Interfacial peptides of HIV-1 protease were crosslinked with varying length alkyl-chains containing either a single cis or trans double bond, or a triple bond to remove degrees of freedom within the tethers. The synthesis of these compounds and their effects on the activity of HIV-1 protease are described.