Restricting the flexibility of crosslinked, interfacial peptide inhibitors of HIV-1 protease

DOI: 10.1016/S0960-894X(98)00595-2

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3281 - 3286 (1998)

Update date:2022-07-30

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Authors:

Ulysse, Luckner G.

Chmielewski, Jean

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Article abstract of DOI:10.1016/S0960-894X(98)00595-2

Interfacial peptides of HIV-1 protease were crosslinked with varying length alkyl-chains containing either a single cis or trans double bond, or a triple bond to remove degrees of freedom within the tethers. The synthesis of these compounds and their effects on the activity of HIV-1 protease are described.

Full text of DOI:10.1016/S0960-894X(98)00595-2

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