Bioorganic and Medicinal Chemistry Letters p. 3281 - 3286 (1998)
Update date:2022-07-30
Topics:
Ulysse, Luckner G.
Chmielewski, Jean
Interfacial peptides of HIV-1 protease were crosslinked with varying length alkyl-chains containing either a single cis or trans double bond, or a triple bond to remove degrees of freedom within the tethers. The synthesis of these compounds and their effects on the activity of HIV-1 protease are described.
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