Enantioselective carbanion cyclization of 5-alkenyl carbamates induced by asymmetric lithiation with s-butyllithium/(-)-sparteine system

Article abstract of DOI:10.1016/S0040-4039(98)02233-3

Treatment of (E)-6-phenyl-5-hexenyl carbamates with s-BuLi/(-)-sparteine is shown to afford the trans-1,2-disubstituted cyclopentane derivatives in high % ee, along with the bicyclo[3.1.0]hexanes (bicyclization products).