Bioorganic and Medicinal Chemistry Letters p. 1553 - 1556 (2001)
Update date:2022-07-31
Topics:
Michaelides, Michael R.
Dellaria, Joseph F.
Gong, Jane
Holms, James H.
Bouska, Jennifer J.
Stacey, Jamie
Wada, Carol K.
Heyman
Curtin, Michael L.
Guo, Yan
Goodfellow, Carole L.
Elmore, Ildiko B.
Albert, Daniel H.
Magoc, Terrance J.
Marcotte, Patrick A.
Morgan, Douglas W.
Davidsen, Steven K.
A novel series of biaryl ether reverse hydroxamate MMP inhibitors has been developed. These compounds are potent MMP-2 inhibitors with limited activity against MMP-1. Select members of this series exhibit excellent pharmacokinetic properties with long elimination half-lives (7 h) and high oral bioavailability (100%).
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(2001)