Structure-activity relationship at the proximal phenyl group in a series of non-peptidyl N-type calcium channel antagonists

DOI: 10.1016/S0960-894X(99)00405-9

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2453 - 2458 (1999)

Update date:2022-07-31

Topics:

Authors:

Ryder, Todd R.

Hu, Lain-Yen

Rafferty, Michael F.

Lotarski, Susan M.

Rock, David M.

Stoehr, Sally J.

Taylor, Charles P.

Weber, Mark L.

Miljanich, George P.

Millerman, Elizabeth

Szoke, Balazs G.

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Article abstract of DOI:10.1016/S0960-894X(99)00405-9

Selective N-Type Voltage Sensitive Calcium Channel (VSCC) antagonists have shown utility in several models of pain and ischemia. We report the structure-activity relationship at the proximal phenyl group in a series of non-peptidyl VSCC blockers.

Full text of DOI:10.1016/S0960-894X(99)00405-9

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