First total synthesis of a new tetrasubstituted pyrrolidine alkaloid, broussonetine C

Article abstract of DOI:10.1016/S0040-4039(98)02605-7

An efficient and stereodefined process is described for the first asymmetric synthesis of a tetrasubstituted pyrrolidine alkaloid, broussoneitne C, as a potent β-galactosidase and β-mannosidase inhibitor by featuring the elaboration through asymmetric deoxgenation of a homochiral C₂-imide and stereoselective reduction of its derivative.