Synthesis of isoindolo[1,3]benzoxazine derivatives through intramolecular arylation of N-acyliminium ions

DOI: 10.1002/jhet.5570350644

Source and publish data:

Journal of Heterocyclic Chemistry p. 1477 - 1483 (1998)

Update date:2022-08-03

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Authors:

Hucher, Nicolas

Daich, Adam

Decroix, Bernard

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Article abstract of DOI:10.1002/jhet.5570350644

[1,3]Benzoxazines annulated to isoindole as 3 and 4 have been synthesized in three steps from N-chloromethylphthalimide 5 and substituted phenols 6. The key step was the acid-catalyzed cyclization of ω-carbinol lactams 8 and 9.

Full text of DOI:10.1002/jhet.5570350644

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