Synthesis of isoindolo[1,3]benzoxazine derivatives through intramolecular arylation of N-acyliminium ions

Article abstract of DOI:10.1002/jhet.5570350644

[1,3]Benzoxazines annulated to isoindole as 3 and 4 have been synthesized in three steps from N-chloromethylphthalimide 5 and substituted phenols 6. The key step was the acid-catalyzed cyclization of ω-carbinol lactams 8 and 9.