Tetrahedron p. 2381 - 2388 (1999)
Update date:2022-09-26
Topics:
El Ashry, El Sayed H.
Abdel-Rahman, Adel A.-H.
El Kilany, Yeldez
Schmidt, Richard R.
The N-([β-hydroxyethyl)acetamidine (4) was prepared. Mesylation of 8 gave the 1,3-di-O-benzyl-2-O-methanesulfonyl-glycerol (9). Nucleophilic displacement of the mesyloxy group in 9 with ethanolamine and morpholine gave 11 and 12, respectively. Their catalytic hydrogenation gave 2-deoxy-2-(1- hydroxyeth-2-yl)amino-glycerol (5) and 2-deoxy-2-(morpholin-4-yl)glycerol (13). The inhibition of the β-D-glucosidase enzyme from sweet almond by 4, 5 and 13-16 has been studied.
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Doi:10.1016/S0040-4039(99)00091-X
(1999)Doi:10.1016/S0040-4039(99)00608-5
(1999)Doi:10.1016/S0040-4039(99)00252-X
(1999)Doi:10.1021/ja9840293
(1999)Doi:10.1016/S0277-5387(00)84556-8
(1986)Doi:10.1207/S15327841Mpee0402_6
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