The synthesis of asimilobin and the correction of its tetrahydrofuran segment's configuration

Article abstract of DOI:10.1016/S0040-4039(98)02577-5

A highly efficient synthetic method for the trans/threo/trans- bis- tetrahydrofuran (THF) ring building block was established. The title compound was synthesized in thirteen steps from trans-1,4-dichloro-2-butene via a convergent route with a Wittig reaction as the key step. The absolute configuration of the THF segment of naturally occurring asimilobin should be corrected.