Substrate specificity of 2-deoxy-scyllo-inosose synthase, the starter enzyme for 2-deoxystreptamine biosynthesis, toward deoxyglucose-6-phosphates and proposed mechanism.

DOI: 10.1271/bbb.62.2396

Source and publish data:

Bioscience, Biotechnology and Biochemistry p. 2396 - 2407 (1998)

Update date:2022-08-03

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Authors:

Iwase Iwase

Kudo Kudo

Yamauchi

Kakinuma

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Article abstract of DOI:10.1271/bbb.62.2396

A crucial enzyme in the biosynthesis of the 2-deoxystreptamine aglycon of clinically important aminocyclitol antibiotics is 2-deoxy-scyllo-inosose synthase (DOIS), which is responsible for the initial carbocycle formation of 2-deoxy-scyllo-inosose (1) fro

Full text of DOI:10.1271/bbb.62.2396

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