Chemical and Pharmaceutical Bulletin p. 423 - 427 (1999)
Update date:2022-08-03
Topics:
Iguchi, Shin
Kawasaki, Koichi
Okamoto, Hiroshi
Umezawa, Chisae
Okada, Yoshio
Some pseudo-peptide analogs of thiol proteinase inhibitors were synthesized by a conventional solution method. Among them, Suc-Ala-Val-Val- Ala-Ψ-(CH2-NH)-Ala-pNA (peptide 1) and Suc-Ala-Val-Val-Ψ-(CH2NH)-Ala- Ala-pNA (peptide 2) showed a stronger inhibitory activity compared with parent peptide such as Suc-Ala-Val-Val-Ala-Ala-pNA. In particular, peptide 2 was about 10-fold as active as the parent peptide (IC50=8 μM). Inserting Ψ-(CH2-NH) possibly makes the inhibitor less susceptible to papain and, as a result, pro-duces more potent inhibition.
View MoreXI'AN CHUKANG BIOTECHNOLOGY CO.,LTD
Contact:29-63685658 63685359
Address:Room 3-1202,Building 1,Oriental oasis,East of Xianning Road,Xi'an,Shaanxi 710043 P.R.China
Contact:+86-0512-69209969
Address:Room 317,Lushan Road,Suzhou New District,Jiangsu Province,China.
Contact:86-575-86132822，86-575-86085355
Address:No.418 Dadao West Road,Qixing Street,Xinchang, Zhejiang Province, China.
Contact:+86-511-88790000
Address:338 North Yushan Rd, Zhenjiang, Jiangsu 212016
Contact:0086-22-23410962
Address:17-201, Ningfuli, Shuishanggongyuandong road,Nankai district, Tianjin, China
Doi:10.1016/S0022-328X(98)00972-3
(1999)Doi:10.1002/(SICI)1099-0690(200001)2000:1<51::AID-EJOC51>3.0.CO;2-K
(2000)Doi:10.1021/ja00284a042
(1986)Doi:10.1021/jo9515687
(1996)Doi:10.1016/S0040-4039(00)73024-3
(1994)Doi:10.1002/jhet.5570360115
(1999)
