The macrocyclic domain of phorboxazole A. A stereoselective synthesis of the C1-C32 macrolactone

DOI: 10.1016/S0040-4039(99)00210-5

Source and publish data:

Tetrahedron Letters p. 2291 - 2294 (1999)

Update date:2022-08-05

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Authors:

Williams, David R.

Clark, Michael P.

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Article abstract of DOI:10.1016/S0040-4039(99)00210-5

A stereoselective synthesis of the C₁-C₃₂ macrocyclic domain of phorboxazole A is described. Key steps have examined the convergent linkage of two major components for the formation of the C₁₉-C₂₀ (E)-alkene, and the subsequent intramolecular (Z)-olefination at C₂-C₃ for ring closure of the macrocycle.

Full text of DOI:10.1016/S0040-4039(99)00210-5

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