Synthesis of 2',3'-dideoxy-3'-C-(hydroxymethyl)-4'-thiopentofuranosyl nucleosides as potential antiviral agent

Article abstract of DOI:10.1016/S0960-894X(99)00142-0

1-O-Acetyl-2,3-dideoxy-3-C-(hydroxymethyl)-4-thiofuranose derivative was synthesized from (S, S)-1,4-bis(benzyloxy)-2,3-epoxybutane derived from (+)- diethyl L-tartrate and the enantiomerically pure (E)-5(2-bromovinyl)-1-[2', 3'-dideoxy-3'-C-(hydroxymethy