Synthesis of cancer peptide antigen-lipid A analog conjugates for synthetic vaccines

DOI: 10.1248/cpb.47.563

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 563 - 568 (1999)

Update date:2022-09-26

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Authors:

Ikeda, Kiyoshi

Miyajima, Keisuke

Maruyama, Yasufumi

Achiwa, Kazuo

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Article abstract of DOI:10.1248/cpb.47.563

Conjugates 6 and 7 of cancer peptide antigen with N-tetradecanoyl L- serine-β-alanine-containing D-glucosamine derivative structurally related to lipid A as an immunoadjuvant were synthesized for the development of totally synthetic vaccines against cancers. The mitogenic activities of compounds 6 and 7 were stronger than that of lipid A analog 3.

Full text of DOI:10.1248/cpb.47.563

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