Synthetic Communications p. 3897 - 3905 (2003)
Update date:2022-08-04
Topics: Synthesis Chemical reactions Selective Experimental Methods Practical Penciclovir
Toyokuni, Tatsushi
Walsh, Joseph C.
Namavari, Mohammad
Shinde, Shirin S.
Moore, Jennifer R.
Barrio, Jorge R.
Satyamurthy, Nagichettiar
A selective and practical method has been developed for the synthesis of penciclovir (1) in gram quantities involving a highly N9 selective alykylation of 2-amino-6-chloropurine (9) with 2-(2-phenyl-1,3-dioxane-5-yl)ethanol (12) as a key step.
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