Heterocycles p. 1331 - 1335 (1998)
Update date:2022-07-30
Topics:
Hayashi, Masahito
Sai, Hiroshi
Horikawa, Hiroshi
The formation of the skeleton of 1,3-benzodiazepin-2-one could be efficiently achieved by intramolecular Heck reaction. This methodology was well applicable to the preparation of optically pure 4-substituted 1,3-benzodiazepin-2-ones starting from easily available α-amino acids.
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