A novel synthesis of 1,3-benzodiazepin-2-ones using intramolecular heck reaction

Article abstract of DOI:10.3987/com-98-8163

The formation of the skeleton of 1,3-benzodiazepin-2-one could be efficiently achieved by intramolecular Heck reaction. This methodology was well applicable to the preparation of optically pure 4-substituted 1,3-benzodiazepin-2-ones starting from easily available α-amino acids.