Bioorganic and Medicinal Chemistry Letters p. 1323 - 1328 (1999)
Update date:2022-08-03
Topics: Synthesis Solid-phase synthesis Yield Cleavage Mass spectrometry (MS) Deprotection HPLC (high-performance liquid chromatography) NMR (nuclear magnetic resonance) Analogues Structure-Activity Relationship (SAR) Coupling Reaction Purity Resin Agonist Receptor binding assay Linker Fmoc chemistry
Cottney
Rankovic
Morphy
Focused libraries of delta opioid ligands were synthesised using REM resin methodology. Several high affinity compounds were identified with good selectivity over the g opioid receptor. Automated REM resin recycling was used to synthesise larger amounts o
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