Bioorganic and Medicinal Chemistry Letters p. 1023 - 1028 (1999)
Update date:2022-07-29
Topics:
Antolini, Marinella
Bozzoli, Andrea
Ghiron, Chiara
Kennedy, Gordon
Rossi, Tino
Ursini, Antonella
A preliminary exploration of analogues of 4,5-bis(3,5-dichlorophenyl)- 2-trifluoromethyl-1H-imidazole, 1, as novel antibacterial agents was carried out to determine the basic features of the structure responsible for the observed biological activity. The presence of two aryl rings, the imidazole NH and either a good electron withdrawing group or an aldehyde or amino group at C-2 were required for good levels of activity against methicillin resistant Staphylococcus aureus (MRSA).
View Morezhenjiang runjing high purity chemical co ltd
Contact:+86-511-83361155
Address:No.8.haixi road,international chemical park
Jiangsu Fengshan Group Co., Ltd.
Contact:86-25-86558671
Address:1903,Central International Mansion 105-6 North Zhongshan Road, Nanjing, China
KA-SHING Business Trade Macau Co., Ltd.
Contact:00853-28430045
Address:23rd Floor, Block 3 La Cite, Areia Preta, Macao
Contact:+86-15527136576
Address:Wuhan city
Shanghai Hongbang Medical Technology CO.,. Ltd
Contact:13671516988 /18917636693
Address:Room1, No67 Building, Yongde Road369, Wujing Town, Minhang Districy, Shanghai CIty, China.
Doi:10.1021/ja00331a029
(1984)Doi:10.1016/0022-1139(96)03400-8
(1996)Doi:10.1016/0040-4020(68)88100-1
(1968)Doi:10.1021/jo9602433
(1996)Doi:10.1039/cc9960001475
(1996)Doi:10.1021/om9604031
(1996)