
Tetrahedron Letters p. 4309 - 4312 (1999)
Update date:2022-08-02
Topics:
Martins, Marcos A.P.
Bastos, Giovani P.
Bonacorso, Helio G.
Zanatta, Nilo
Flores, Alex F.C.
Siqueira, Geonir M.
The regiochemistry of the acylation of enol ethers, generated in situ, from acetals of unsymmetrical ketones is reported. These results demonstrate a convenient one-pot method to obtain a series of β-methoxyvinyl trichloromethyl ketones [CCl3COCH=C(OMe)R, where R=Et, n-Bu, i-Pt, (CH2)2C(OMe)=CHC(O)CCl3 and (CH2)5CO2CH3)] in high yields.
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