The enantioselective total synthesis of the antitumor macrolide natural product rhizoxin D

DOI: 10.1016/S0040-4039(99)00731-5

Source and publish data:

Tetrahedron Letters p. 4145 - 4148 (1999)

Update date:2022-08-04

Topics:

Authors:

Lafontaine, Jennifer A.

Provencal, David P.

Gardelli, Cristina

Leahy, James W.

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Article abstract of DOI:10.1016/S0040-4039(99)00731-5

A convergent, enantioselective total synthesis of rhizoxin D (didesepoxy-rhizoxin), a potent antitumor natural product, was achieved via three critical olefinations, including a Horner-Emmons macrocyclization.

Full text of DOI:10.1016/S0040-4039(99)00731-5

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