Bioorganic and Medicinal Chemistry Letters p. 1371 - 1374 (1999)
Update date:2022-08-04
Topics:
Ma, Dawei
Wang, Guoqiang
Wang, Shaomeng
Kozikowski, Alan P.
Lewin, Nancy E.
Blumberg, Peter M.
Benzolactam-V7 (3a), a simplified analogues of (-)-indolactam-V with twist-form conformation, was synthesized and evaluated as a new protein kinase C modulator. Both 3a and its-7-substituted analogue 3c showed weak binding activity to displace PDBU binding from recombinant PKCα.
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