Synthesis and protein kinase C binding activity of benzolactam-V7

DOI: 10.1016/S0960-894X(99)00207-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1371 - 1374 (1999)

Update date:2022-08-04

Topics:

Authors:

Ma, Dawei

Wang, Guoqiang

Wang, Shaomeng

Kozikowski, Alan P.

Lewin, Nancy E.

Blumberg, Peter M.

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Article abstract of DOI:10.1016/S0960-894X(99)00207-3

Benzolactam-V7 (3a), a simplified analogues of (-)-indolactam-V with twist-form conformation, was synthesized and evaluated as a new protein kinase C modulator. Both 3a and its-7-substituted analogue 3c showed weak binding activity to displace PDBU binding from recombinant PKCα.

Full text of DOI:10.1016/S0960-894X(99)00207-3

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