Synthesis and characterization of lipophilic 1-[18F]fluoroalkyl-2- nitroimidazoles for imaging hypoxia

DOI: 10.1248/bpb.22.590

Source and publish data:

Biological and Pharmaceutical Bulletin p. 590 - 597 (1999)

Update date:2022-08-04

Topics:

Authors:

Yamamoto, Fumihiko

Oka, Hidenobu

Antoku, Shigetoshi

Ichiya, Yu-Ichi

Masuda, Kouji

Maeda, Minoru

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Article abstract of DOI:10.1248/bpb.22.590

In order to develop new imaging markers for brain hypoxia, two lipophilic nitroimidazoles, 1-(3-fluoropropyl)-2-nitroimidazole (FPN) and 1- (8-fluorooctyl)-2-nitroimidazole (FON) were synthesized and labeled with fluorine-18. The octanol/water partition c

Full text of DOI:10.1248/bpb.22.590

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