Stereoselective synthesis of (+)-CP-99,994: A substance P non-peptide antagonist

Article abstract of DOI:10.1016/S0040-4039(99)00983-1

A highly stereoflexible total synthesis of (+)-CP-99,994 is achieved starting, from (S)-serine, key steps being a diastereoselective Grignard addition, a one-pot reductive protection of an azide, and one-pot oxidative Wittig olefination.