Nonpeptidic HIV protease inhibitors: 6-Alkyl-5, 6-dihydropyran-2-ones possessing achiral 3-(4-amino/carboxamide-2-t-butyl, 5-methylphenyl thio) moiety: Antiviral activities and pharmacokinetic properties

DOI: 10.1016/S0960-894X(99)00237-1

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1481 - 1486 (1999)

Update date:2022-08-05

Topics:

Authors:

Vara Prasad

Boyer, Fred E.

Domagala, John M.

Ellsworth, Edmund L.

Gajda, Christopher

Hagen, Susan E.

Markoski, Larry J.

Tait, Bradley D.

Lunney, Elizabeth A.

Tummino, Peter J.

Ferguson, Donna

Holler, Tod

Hupe, Donald

Nouhan, Carolyn

Gracheck, Stephen J.

VanderRoest, Steven

Saunders, James

Iyer, Krishna

Sinz, Michael

Brodfuehrer, Joanne

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Article abstract of DOI:10.1016/S0960-894X(99)00237-1

Dihydropyran-2-ones possessing amino and carboxamide functionalities on 3-SPh (2-tert-butyl, 5-methyl) ring were synthesized and evaluated for their antiviral activities. Both the enantiomers of inhibitor 15 were synthesized. The in vitro resistance profi

Full text of DOI:10.1016/S0960-894X(99)00237-1

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