Total synthesis of (+)-(2S,3R)-piscidic acid via catalytic asymmetric dihydroxylation of a trisubstituted olefin

Article abstract of DOI:10.1271/bbb.63.964

(+)-(2S,3R)-Piscidic acid was efficiently synthesized with high optical purity (90% e.e.) via Sharpless catalytic asymmetric dihydroxylation of a trisubstituted olefin in only 6 steps from commercially available 4-hydroxyphenylpyruvic acid as the starting