An improved synthetic approach to thieno[2,3-d]-1,2,3-thiadiazole- carboxylates via diazotization of aminothiophene derivatives

Article abstract of DOI:10.1002/jhet.5570360330

The common synthetic method for the synthesis of fused 1,2,3- thiadiazoles via diazotization is not generally applicable to aminothiophenes. A substantially improved experimental protocol for the preparation of the title compounds as a potential inducer of systemic acquired resistance in plants is reported based on a novel cyclization mechanism via a Huisgen-White type rearrangement.