Tetrahedron Letters p. 5655 - 5659 (1999)
Update date:2022-09-26
Topics:
Hepperle, Michael
Eckert, Jeffrey
Gala, Dinesh
A simple sequential N-arylation of piperazine without the use of a protecting group, catalyst, specialized equipment or a large excess of piperazine, and its application towards the preparation of the key differentially N,N'-biarylated piperazine antifungal intermediate N-(4-hydroxyphenyl)-N'-(4-aminophenyl)piperazine, 6, is described.
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