Preparation of crystalline p-nitrobenzyl 2-formyl carbapenems by oxidative cleavage

DOI: 10.1016/S0960-894X(99)00249-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1559 - 1562 (1999)

Update date:2022-08-04

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Authors:

Hsiao, Yi

Wells, Kenneth M.

Yang, Chunhua

Jensen, Mark S.

Chung, John Y.L.

Yasuda, Nobuyoshi

Hughes, David L.

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Article abstract of DOI:10.1016/S0960-894X(99)00249-8

Crystalline 1β-methyl-2-formyl carbapenem pNB esters were prepared by osmium-mediated oxidative cleavage of the corresponding 2-vinyl derivatives. Reduction of the 2-formyl compounds gave the corresponding 2-hydroxymethyl derivatives, which are key interm

Full text of DOI:10.1016/S0960-894X(99)00249-8

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