Optimization of tether length in nonglycosidically linked bivalent ligands that target sites 2 and 1 of a Shiga-like toxin

DOI: 10.1021/ja0258529

Source and publish data:

Journal of the American Chemical Society p. 3284 - 3294 (2003)

Update date:2022-07-30

Topics:

Authors:

Kitov, Pavel I.

Shimizu, Hiroki

Homans, Steven W.

Bundle, David R.

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Article abstract of DOI:10.1021/ja0258529

A series of bivalent ligands for a Shiga-like toxin have been synthesized, their experimentally determined inhibitory activities were compared with a simplified thermodynamic model, and computer simulations were used to predict the optimal tether length i

Full text of DOI:10.1021/ja0258529

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