Synthesis of new lipophilic acyclic di-ionizable polyethers, bis(crown ethers) and macrocyclic diamides

Article abstract of DOI:10.1016/S0040-4020(99)00514-1

A series of new lipophilic acyclic polyethers containing two carboxylic or hydroxamic acid groups have been prepared. From lipophilic acyclic polyether dicarboxylic acids 2, 9 and 13, the bis(crown ethers) 20-25 were synthesized. From lipophilic acyclic polyether dicarboxylic acids 10-12 and 14, the new macrocyclic diamides 26-32 were prepared in high yields without the use of high dilution techniques or template effects.