Synthesis and structure-activity relationship of a new series of potent angiotensin II receptor antagonists: Pyrazolo[1,5-α]pyrimidine derivatives

DOI: 10.1248/cpb.47.928

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 928 - 938 (1999)

Update date:2022-07-30

Topics:

Authors:

Shiota, Takeshi

Yamamori, Teruo

Sakai, Katsunori

Kiyokawa, Mitsugu

Honma, Tsunetoshi

Ogawa, Masayoshi

Hayashi, Kunio

Ishizuka, Natsuki

Matsumura, Ken-Ichi

Hara, Mariko

Fujimoto, Masafumi

Kawabata, Tomoji

Nakajima, Shigeyuki

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Article abstract of DOI:10.1248/cpb.47.928

We have already reported 7-oxo-4,7-dihydropyrazolo[1,5-α]pyrimidine-3- carboxylic acid derivatives, which are potent in vitro angiotensin II (AII) antagonists, but have no oral antihypertensive activity. Removal of the carboxylic acid and replacement of t

Full text of DOI:10.1248/cpb.47.928

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