Synthesis and structure-activity relationship of a new series of potent angiotensin II receptor antagonists: Pyrazolo[1,5-α]pyrimidine derivatives

DOI: 10.1248/cpb.47.928

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 928 - 938 (1999)

Update date:2022-07-30

Topics:

Authors:

Shiota, Takeshi

Yamamori, Teruo

Sakai, Katsunori

Kiyokawa, Mitsugu

Honma, Tsunetoshi

Ogawa, Masayoshi

Hayashi, Kunio

Ishizuka, Natsuki

Matsumura, Ken-Ichi

Hara, Mariko

Fujimoto, Masafumi

Kawabata, Tomoji

Nakajima, Shigeyuki

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.47.928

We have already reported 7-oxo-4,7-dihydropyrazolo[1,5-α]pyrimidine-3- carboxylic acid derivatives, which are potent in vitro angiotensin II (AII) antagonists, but have no oral antihypertensive activity. Removal of the carboxylic acid and replacement of t

Full text of DOI:10.1248/cpb.47.928

NII-Electronic Library Service

Products guided by the article

Product name:5-ethyl-3-phenyl-4H-pyrazolo<1,5-a>pyrimidin-7-one

Cas No:244127-37-5

R&D Labs maybe for 244127-37-5

Shanghai birch chemical technology co.,ltd

Contact:+86-21-54096810

Address:No.2588,Jungong Road,Shanghai,China
Qingdao Kylin Trading Co., Ltd.

Contact:0086-532-68979884/58972912/68972263/65/88171519

Address:Room 2308,A building International Trade Center No.230 Changjiang Middle Road of Qingdao Economic Development Zone,Shandong,China.
Hefei EnliPharma Tecnology Co.,Ltd

Contact:0086-551-66399836

Address:Qing Cheng ShuiXiang Building 805, Mengcheng North Road , ShuangFeng Economic Development Zone Anhui HeFei
TIANJIN NORTH JINHENG CHEMICAL PLANT.

Contact:0086-22-59952083

Address:DongShigu Country In JiXian TianJin China
Quzhou Aokai Chemical Co., Ltd.

Contact:86-570-3032832

Address:NO.16 , Laodong Road,Quzhou City, Zhejiang Province,China

Relevant to this article

Spectroscopy and reactivity of zinc 20-oxaporphyrin-IX dimethyl ester

Doi:10.1002/recl.19871060401
(1987)
(+)-Jaborol, an unusual phenolic withanolide from Jaborosa magellanica

Doi:10.1016/S0040-4020(01)81669-0
(1987)
Catalytic redox-initiated glycolate aldol additions of silyl glyoxylates

Doi:10.1021/ol802828d
(2009)
Synthetic and mechanistic aspects of the reactions between bromodifluoromethyltriphenylphosphonium bromide and dibromofluoromethyltriphenylphosphonium bromide and trialkylphosphites

Doi:10.1016/j.jfluchem.2008.04.003
(2008)
Synthesis and antituberculosis activity of certain steroidal derivatives of the 5α-series

Doi:10.1007/s10600-008-9126-8
(2008)
Enzymatic synthesis of fatty hydroxamic acid derivatives based on palm kernel oil

Doi:10.3390/molecules16086634
(2011)

Article Doi